THE NON-ENZYMATIC OXIDATION OF α-KETOGLUTARATE
نویسندگان
چکیده
منابع مشابه
Non-enzymatic oxidation of tyrosine and dopa.
4Winge, 0., and Roberts, C., Comp. Rend. Trav. Lab., Carlsb., Ser. Physiol., 24, 263-315 (1948). 5 Ryan, F. J., and Schneider, L. K., Genetics, 34, 72-91 (1949). 6 Luria, S. E., and Delbruck, M., Ibid., 28, 491-511 (1943). 7Mundkur, B., and Lindegren, C. C., Am. J. Botany, 36, 722-727 (1949). 8 Lea, D. E., and Coulson, C. A., J. Genetics, 49, 264-285 (1949). 9Spiegelman, S., Cold Spring Harbor ...
متن کاملUptake of α-ketoglutarate by the citrate transporter CitP drives
4 Agata M. Pudlik and Juke S. Lolkema 5 6 1 Top Institute Food and Nutrition, Wageningen, The Netherlands. 2 Molecular Microbiology, 7 Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 8 Groningen, The Netherlands. 3 The Kluyver Centre for Genomics of Industrial Fermentations 9 / NCSB, Delft, The Netherlands. 10 11 * correspondence 12 J.S. Lolkema, Center for...
متن کاملInactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.
Reduced brain metabolism is an invariant feature of Alzheimer Disease (AD) that is highly correlated to the decline in brain functions. Decreased activities of key tricarboxylic acid cycle (TCA) cycle enzymes may underlie this abnormality and are highly correlated to the clinical state of the patient. The activity of the α-ketoglutarate dehydrogenase complex (KGDHC), an arguably rate-limiting e...
متن کاملOxidation cyclischer α-Aminoketone Oxidation of Cyclic α-Aminoketones
The 1,2,3,4-tetrahydro-isoquinolin-4-one 4 reacts as an α-amino ketone with periodate to give various products, the major compound being 1-hydroxy-1,2-dihydro-3,4-isoquinolinedione 12. Upon stepwise oxidation with Hg(II)-EDTA the 4-hydroxyisoquinolinium ion 14 is detected as an intermediate and its further oxidation with periodate gives rise to an almost identical product spectrum. Because 12 r...
متن کاملThe α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell's change in b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64874-4